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This makes Devil’s Lettuce a good choice for consumers seeking a strain that induces a strong psychotropic high. Sedation sets in and the body goes into deep relaxation making it a great strain to be used in the evenings. It has indica effects, with more blissful and relaxing thoughts putting your mind at ease. So be careful when using this strain as it may cause a couch-lock effect. Some users have claimed it may cause dry mouth, dry eyes and increased appetite.